Paeoniflorin Diminishes Maximal Electroshock - and PTZ - induced Convulsions in Mice

Paeonia Radix is one of the most commonly used herbal drug in traditional Chinese medicine1 and folkloric medicine of different countries since ancient times2. A number of chemical and pharmacological studies have been conducted on the roots of Paeonia species. Monoterpen glycosides are the active constituents, among them; paeoniflorin is the main compound in genus Paeonia3. In traditional medicine aqueous decoctions of Paeonia have been used against several types of seizures1,4,5.